I am a research scholar working in the field of computational biology. My research area comprises of genetic and functional aspects implicated in DNA repair, associated disorders and pathways. My main focus is on the quantitative genetic study of the genes involved in several mechanisms of repair, analysis of SNPs and other genetic variations and also looking at the effect of these mutations at structural level.
Academic Profile
DST Research Scholar at JUIT, Waknaghat
PhD Topic: "Identification and analysis of biomarkers implicated in DNA repair system".
Gold medalist of KUK University in Bachelor of Sciences with 82.2%
Qualified Graduate Aptitude Test in Engineering (GATE) 2011 with 90.22 percentile
Stood First in MSc.Bioinformatics in D.A.V College, Panjab University, Chandigarh with 79.9%
Summer Internship/scholarship (May-June 2011) from Indian Institute of Science and Eucational Research (IISER), Mohali
Second prize in The Woman Study Cell’s English Declamation and Poetic Recitation. Topic: The Decline in Sex Ratio and the Role of Woman in it
Participated in college and school level debates, painting, swimming, Singing, paper reading, poetic recitation, dancing, modeling and essay writing competitions and received applauds
Research Interests
Computational biology, systems biology, drug desiging, structural biology, functional genomics, database development, protein-protein interactions, pathway analysis, quantitative genetic association studies and identification and analysis of single nucleotide polymorphisms.
Projects/Trainings
B.Sc. Project: “Studying and analyzing in silico drug designing tools and resources”
M.Sc. Project: “In silico structure based drug designing for dopamine receptor D2 (DRD2), a therapeutic target for schizophrenia”
A year diploma in Information Technology from National Institute of Information Technology (NIIT), Yamuna Nagar, Haryana, India
Summer Internship from Indian Institute of Science Education and Research (IISER), Mohali, India for the period May-July, 2011
Training in MS Office, C, C++ and other basics in computer applications from Kips India
Training on computational drug designing from DNA Research Centre, Zirakpur, Panjab, Inida
Training in programming languages like C++ and C# from Hartron, Haryana, India
Training from ADI Biosolutions, Mohali, India on target identification, molecular modeling and in silico structure based drug designing
Research Experience
Experience in handling numerous biological problems with sequence, structure and phylogenetic information using different tools and servers
Dealing with complex datasets, analyzing and applying different integrative approaches from past 5-6 years
Languages : C, C++, C#, Java, Perl, PHP, JavaScript
DBMS Packages : SQL SERVER 2005, MySQL
Operating System: Windows 98, 2000, XP, 7, Solaris
Web Designing : HTML, XML, DBMS and Data Structures
Developed a database, DRGAS: DNA Repair Genetic Association Studies, accessible at http://www.bioinfoindia.org/drgas/
Publications
Manika Sehgal and Tiratha Raj Singh, Identification and analysis of biomarkers for mismatch repair proteins: A bioinformatic approach, JNSBM. 3 (2012) 139-146
Manika Sehgal and Tiratha Raj Singh, DR-GAS: A database of functional genetic variants and their phosphorylation states in human DNA repair systems, DNA Repair. 16 (2014) 97-103
Manika Sehgal and Tiratha Raj Singh, Systems biology approach for mutational and site-specific structural investigation of DNA repair genes for xeroderma pigmentosum, Gene . (2014) [In Press]
Conferences/ Symposia/ Workshops
Presented paper entitled "Quantitative Genetic Analysis of DNA Repair Genes Implicated in Xeroderma Pigmentosum" at The Third International Federation for Information Processing (IFIP) International Conference on Bioinformatics in Maulana Azad National Institute of Technology (MANIT), Bhopal, Madhya Pradesh, INDIA from 23-26, September 2013 (Oral Presentation)
Presented paper entitled "Identification and Analysis of Biomarkers for Mismatch Repair Proteins: A Bioinformatic Approach" at The International Interdisciplinary Science Conference (I-ISC, 2011) on Bioinformatics: An interface between Computer Science and Biology in Jamia Millia Islamia, New Delhi, INDIA from 15-17, November 2011 (Oral Presentation)
National Symposium on The Recent Trends in Bioinformaticsheld at Panjab University, Chandigarh, INDIA on 26th April, 2011
Workshop on Data Mining and Parallel Computing jointly organized by Jaypee University of Information Technology & University of Florida at Waknaghat, Solan, INDIA from 2-5, August, 2011
A Bioinformatics workshop jointly organized by University of Nebraska, Omaha, USA and JUIT, Waknaghat, HP, INDIA from 8-10, May, 2013
National workshop on In silico approaches for designing bioactive peptides held at IMTECH, Chandigarh, INDIA from 18-21, October 2011
Resource Person for scripting languages in summer training at Jaypee University, Waknaghat, (HP), INDIA from June-July, 2013
Resource Person in The 19th Workshop on Pathways and System-Integrated Approaches at Bioinfo Centre, Himachal Pradesh University (HPU), Shimla (HP), INDIA from 16-19, September, 2013
Leadership Activities/ Appointments
Resource Person for teaching and taking labs of scripting languages in summer training held at Jaypee University of Information Technology, Solan, (H.P.), India from June-July, 2013
Resource Person in “The 19th Workshop on Pathways and System-Integrated Approaches” at Bioinformatics Centre, Himachal Pradesh University (HPU), Shimla (H.P.), India from 16-19, September, 2013
Member of The Woman Study Cell of M.L.N. College, Yamunanagar, Kurukshetra University Kurukshetra
Hobbies
Listening to music, dancing, swimming, skating and reading books.
