Manually Curated Database for NER Specific Skin Cancer
Welcome to NER Specific Skin Cancer Database
DNA damage has emerged as a major culprit in cancer and many age related diseases. This damage to the cells owes to the endogenous stress like translation, or exogenous stresses like exposure to ultraviolet radiations, environmental mutagens, or chemotherapeutic abducts etc. Hence to conserve the genomic integrity and stability, certain labyrinthine repair mechanism is required that can perceive the different types of damage and the checkpoints that counteracts this DNA damage.
One of the most important and the prime pathway to remove this bulky DNA lesions is the Nucleotide Excision Repair pathway, which has a sequential workflow ranging from damage recognition to damage removal, in addition with DNA synthesis. Deficiencies in NER repair proteins are also associated with the skin cancer-prone inherited disorder - Xeroderma Pigmentosum and other neurodegenerative abnormalities like Cockayne Syndrome and Trichothiodystrophy. These cancers are the prime focus of our database.
In our database, we discuss and analyse this DNA damage with respect to cancer repair mechanism in detail as well its biological relevance by description of the biochemistry of the NER process, clinical features of the NER disorders, therapeutic treatments or drugs, followed by genetic and molecular investigation, hence speculating the molecular basis underlying these pleiotropic syndromes.
